Through a “face-name” memory encoding task and a digital symbol substitution, Jinghang Li and Elizabeth Mountz investigated the association between functional activation asymmetry and risk factors of Alzheimer’s Disease. The results indicated that symmetrical activation in subcortical regions was associated with better cognitive performance in memory learning, executive function, and visual spatial domains. Results additionally indicated that genetic risk factors of Alzheimer’s Disease were associated with greater symmetrical activation in cortical regions, and that greater education levels were associated with greater symmetrical activation in subcortical regions.